Erythropoiesis Physiology | Easy to understand | Erythropoiesis notes

 

Erythropoiesis Physiology  Easy to understand  Erythropoiesis notes

DEFINITION 

The red blood cells are in the process of the emergence, development, and maturation of red blood cells. Hematopoiesis or blood formation, is in the process of the emergence, development, and maturation of all blood cells. 

THE FORMATION OF THE RED BLOOD CELLS TO THE AREA 

In embryonic life, the formation of red blood cells takes place in three stages: 

1. Mesoblastic stage in the first two months of intrauterine life, in which the blood of the elements produced in the mesenchyme of the yolk sac. 

2. Live steps away From the third month of intra-uterine life, the liver, the main organ that produces the blood component during the pregnancy. The spleen and lymphoid organs, and also takes part in the formation of red blood cells. 

3. Myeloid plan for the final three months of intra-uterine life in the blood for parts of the red bone marrow, and the liver's production. 

WE, THE NEW-BORN, CHILD, AND ADULT 

I was born and grew up children and adults alike with the blood of the elements that produce only red bone marrow. 

1. As many as 20 years old: in the blood of the production of the elements of the red bone marrow of all the bones (the long bones, and of all the flat bones). 

2. 20 years later, during the blood elements, which are produced by the webbed legs, which vertebral bone, the sternum, ribs, and back to the land, the beat, the hip bone, and the skull, and, bones, and, finally, the long bones. 20 years later, the long legs, the trunk will be the yellow bone marrow is due to fat deposition, and it loses its erythropoietic function. 

We, the adults, the liver, and the spleen is capable of producing cells of the above, the bones, the brain, destroying the fibrotic. In a full glass of the brain, it can be said to be equivalent to that of a living, size, and weight. It is also active, as is the liver. 

Despite the fact that the brain is the site of production of all blood cell count, as compared with 75% of the bone marrow is involved in the production of white blood cells), and only 25% of them are involved in the production of red blood cells. 

THE STAGE OF A RED BLOOD CELL PRODUCTION 

Different stages of the project, between the cells, for SOME it is the th of the mature red blood cells are: 

1. Proerythroblast 

2. At the beginning of the normoblast 

3. Intermediate normoblast. 

4. The late normoblast 

5. Reticulocytes 

6. Mature red blood cells 

THE FACTORS THAT ARE NECESSARY FOR THE FORMATION OF RED BLOOD CELLS 

The development and maturation of red blood cells, which require a variety of factors that can be classified into one of three categories: 

1. The common factors of 

A common factor that is required for the formation of red blood cells is:

I. Erythropoietin

II. Thyroxine

III. Hematopoietic growth factors

iv. Vitamins. 

2. Growth factors 

3. The factors that are necessary for the formation of haemoglobin.

THE FACTORS THAT ARE NECESSARY FOR THE FORMATION OF HEMOGLOBIN 

A variety of materials, which is essential for the formation of haemoglobin in red blood cells. 

The lack of these substances, and a reduction in production of hemoglobin, resulting in anemia. These factors are as follows: 

1. The proteins and amino acids in the first class. the Protein of a high biological value, and is essential for the formation of haemoglobin. Amino acids, which are obtained from the synthesis of the proteins that are needed for this protein as a component of hemoglobin, i.e. the globin. 

2. Requirements: - A portion of the hemoglobin is essential for the formation of heme. 

3. Copper is a prerequisite for the uptake of iron from the gastrointestinal tract. 

4. The cobalt and nickel, These metals are essential for the absorption of the iron in the formation of hemoglobin. 

5. Vitamins such as Vitamin C, riboflavin, nicotinic acid, and pyridoxine are also required for the formation of haemoglobin.

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